Wherever a gene exists on a DNA molecule, one strand is the coding strand (or sense strand ), and the other is the noncoding strand (also called the antisense strand, [3] anticoding strand, template strand or transcribed strand ). Strands in transcription bubble
Antisense therapies are designed to seek out, bind to and destroy a mRNA in a highly specific manner, so that the amount of disease-causing protein is dramatically decreased. RNA interference RNAi In testing the effects of antisense RNA, one should use sense RNA of the same coding region as a control. Biology. Biology questions and answers. Background: The coding sequence (5' 3" "antisense strand") of DNA below leads to the production of a specific protein. That makes it a gene. The gene was sequenced from samples taken from healthy human patients. As a genetic researcher you must first transcribe the sequence into an mRNA sequence. Many prokaryotic RNAs are transcribed from loci outside of annotated protein coding genes. Across bacterial species hundreds of short open reading frames antisense to annotated genes show evidence of both transcription and translation, for instance in ribosome profiling data. Determining the functional fraction of these protein products awaits further research, including insights from studies Antisense inhibition of target gene expression, while necessary for optimal antiviral activity, only partially explains the activity of fomivirsen against CMV. Nonspecific interactions between the oligonucleotide and virus particles may prevent adsorption or lead to inhibition of enzymes required for viral DNA synthesis.an·ti·sense DNA. the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene. Farlex Partner Medical Dictionaryxughg8.